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KMID : 1123920050190030785
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 3 p.785 ~ p.791
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Effects of Corydalis Tuber on Synthesis of NO and in Murine Macrophage RAW 264.7 Cells Stimulated by LPS
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Lee Ki-Young
Park Se-Keun
Kim Jeong-Seon
Jang Mi-Hyeon
Kim Chang-Ju
Choi Sun-Mi
Lee Hye-Jung
Kim E-Hwa
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Abstract
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Corydalis Tuber has traditionally been used for the treatment of water retention in the body. Administration of the aqueous extract of Corydalis Tuber has been known to be effective for the control of pain and treatment of arthritis. It was reported that Corydalis Tuber possesses anti-inflammatory activity and modulates the intestinal immune system. The effect of Corydalis Tuber against LPS-stimulated expressions of COX-2, iNOS, and in cells of the murine RAW 264.7 macrophages was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), immunoassay, and NO detection. The aqueous extract of Corydalis Tuber was shown to suppress production by inhibition on the LPS-stimulated enhancement of COX-2 enzyme activity, , and iNOS expression in the RAW 264.7 macrophages. Present results suggest that Corydalis Tuber exerts anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and expressions, resulting in inhibition of synthesis. Corydalis Tuber has anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and mRNA expressions, resulting in inhibition of and NO synthesis.
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KEYWORD
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Corydalis Tuber, COX-2, Inflammation, iNOS
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